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现ããããïŒWe will measure 10 mg of a sample and put it into an NMR tube and then add 1 mL of deuterated solvent.ïŒæž¬å®ãã10mgã®ãµã³ãã«ãNMRãã¥ãŒãã«æå
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倧ãŸããããïŒWe will use NMR spectroscopy.ïŒNMRåå
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·äœç1ïŒWe plan to use 1H NMR spectroscopy to measure binding constants, through monitoring signal changes of the guest as a function of concentration of host.ïŒãã¹ãã®æ¿åºŠé¢æ°ãšããŠã²ã¹ãã®ä¿¡å·å€åã芳å¯ããããšã§ã1H -NMRåå
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·äœç2ïŒWe will use 1H NMR spectroscopy to measure binding affinities, following well-established literature precedent.ïŒååã«ç¢ºç«ãããå
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6. çºçãåŸãåé¡ãšä»£æ¿ææ³ãè¿°ã¹ãïŒããã¯éåžžã«éèŠã§ããçµéšã®ãã人ãªããç ç©¶ã¯èšç»éãã«é²ãŸãªãããšããããšç¥ã£ãŠããŸããå®éãã»ãšãã©ã®å Žåãäœããã®åé¡ã¯çºçãããã®ã§ããããããŒã¶ã«ã§ã¯ãçºçãåŸãåé¡ãšãããã解決ããããã®å®è¡å¯èœãªä»£æ¿æ¡ãèããŠããããšã瀺ããªããã°ãªããŸãããã¬ãã¥ã¢ãŒã«ãããã®ç³è«è
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·äœçã§ãªããŠã¯ãªããªãç¹ã§ããããšãã°ããA potential problem is that everything will fail,ïŒãã¹ãŠã倱æããå¯èœæ§ãããïŒããšæžãããããI will throw everything in the trash and burn down the building.ïŒãã¹ãŠå»æ£ãã建ç©ãçããïŒããšãã解決çãæžãããããããã«ã¯ãããŸãããããã§ã¯ãªããäŸãã°ä»¥äžã®ããã«æžããŸãããïŒ
çºçãåŸãåé¡ïŒChallenges in characterizing the molecules using spectroscopic techniques may arise due to the high flexibility of the molecular structures.ïŒåå
æè¡ãçšããååã®ç¹æ§è©äŸ¡ã«ãããŠãååæ§é ã®æè»æ§ã®é«ãã«ãã£ãŠåé¡ãçããå¯èœæ§ãããïŒ
ãã®åé¡ã®è§£æ±ºçïŒWe will investigate alternate techniques, including microscopic imaging, to characterize the structures so that we do not rely solely on spectroscopic techniques.ïŒåå
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7. ã¹ã±ãžã¥ãŒã«ãè¿°ã¹ãïŒãçºçãåŸãåé¡ãšä»£æ¿ææ³ããšåæ§ã«ãã¹ã±ãžã¥ãŒã«ãè¿°ã¹ãããšã§ãç ç©¶ã«ã€ããŠè©³çްã«èããŠããããšãšããã®èšç»ãå®çŸå¯èœã§ããããšãã¬ãã¥ã¢ãŒã«ã¢ããŒã«ããããšãã§ããŸãããŸããã¹ã±ãžã¥ãŒã«ãè¿°ã¹ãããšã«ãã£ãŠãç ç©¶ã®ãã£ãšãéèŠãªéšåããã£ãšãæéãèŠããå¯èœæ§ãé«ãéšåãæ¯èŒçè¿
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